The purpose of this course is to describe the background, investigative methods, and recent advances in understanding the molecular basis of selected diseases, with an in-depth focus on a small number of diseases where defects are known at genetic or molecular levels. The course is taught in a small group seminar format by experts in each disease studied. The course content varies from year to year to allow inclusion of the most up to date and exciting advances in our understanding of molecular pathogenesis. The course is open to both medical students and graduate students interested in the application of molecular biology to human disease. A sample of recent course pics is shown below. Grading is based on 2 take-home examinations, a paper & oral presentations on molecular aspects of a disease not covered in class, & class participation. Faculty who coordinate the course include Drs. Dan Kenan, Tim Fields, and Laura Hale.